Treatment and vaccines for severe acute respiratory syndrome
Identifieur interne : 001198 ( Pmc/Checkpoint ); précédent : 001197; suivant : 001199Treatment and vaccines for severe acute respiratory syndrome
Auteurs : David A. Groneberg [Allemagne] ; Susan M. Poutanen [Canada] ; Donald E. Low [Canada] ; Hartmut Lode [Allemagne] ; Tobias Welte [Allemagne] ; Peter Zabel [Allemagne]Source :
- The Lancet. Infectious Diseases [ 1473-3099 ] ; 2005.
Abstract
The causative agent of severe acute respiratory syndrome (SARS), which affected over 8000 individuals worldwide and was responsible for over 700 deaths in the 2002–2003 outbreak, is a coronavirus that was unknown before the outbreak. Although many different treatments were used during the outbreak, none were implemented in a controlled fashion. Thus, the optimal treatment for SARS is unknown. Since the outbreak, much work has been done testing new agents against SARS using in-vitro methods and animal models. In addition, global research efforts have focused on the development of vaccines against SARS. Efforts should be made to evaluate the most promising treatments and vaccines in controlled clinical trials, should another SARS outbreak occur.
Url:
DOI: 10.1016/S1473-3099(05)01307-1
PubMed: 15766649
PubMed Central: 7106466
Affiliations:
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Groneberg</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Pneumology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pneumology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Otto-Heubner-Centre, Pneumology and Immunology, Charité School of Medicine, Free University and Humboldt-University, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Otto-Heubner-Centre, Pneumology and Immunology, Charité School of Medicine, Free University and Humboldt-University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Poutanen, Susan M" sort="Poutanen, Susan M" uniqKey="Poutanen S" first="Susan M" last="Poutanen">Susan M. Poutanen</name><affiliation wicri:level="1"><nlm:aff id="aff3">Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto</nlm:aff><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E" last="Low">Donald E. Low</name><affiliation wicri:level="1"><nlm:aff id="aff3">Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto</nlm:aff><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Medicine, University of Toronto, Toronto</nlm:aff><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lode, Hartmut" sort="Lode, Hartmut" uniqKey="Lode H" first="Hartmut" last="Lode">Hartmut Lode</name><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Chest and Infectious Diseases, Hospital Heckeshorn, Free University Berlin, Berlin</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Berlin</settlement><region type="land" nuts="2">Berlin</region></placeName><wicri:orgArea>Department of Chest and Infectious Diseases, Hospital Heckeshorn, Free University Berlin</wicri:orgArea></affiliation></author><author><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Pneumology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pneumology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Zabel, Peter" sort="Zabel, Peter" uniqKey="Zabel P" first="Peter" last="Zabel">Peter Zabel</name><affiliation wicri:level="1"><nlm:aff id="aff7">Division of Clinical Infectiology and Immunology, Department of Medicine, Research Center Borstel, Borstel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Infectiology and Immunology, Department of Medicine, Research Center Borstel, Borstel</wicri:regionArea><wicri:noRegion>Borstel</wicri:noRegion><wicri:noRegion>Borstel</wicri:noRegion><wicri:noRegion>Borstel</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15766649</idno><idno type="pmc">7106466</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106466</idno><idno type="RBID">PMC:7106466</idno><idno type="doi">10.1016/S1473-3099(05)01307-1</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">001856</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001856</idno><idno type="wicri:Area/Pmc/Curation">001856</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001856</idno><idno type="wicri:Area/Pmc/Checkpoint">001198</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001198</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Treatment and vaccines for severe acute respiratory syndrome</title><author><name sortKey="Groneberg, David A" sort="Groneberg, David A" uniqKey="Groneberg D" first="David A" last="Groneberg">David A. Groneberg</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Pneumology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pneumology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Otto-Heubner-Centre, Pneumology and Immunology, Charité School of Medicine, Free University and Humboldt-University, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Otto-Heubner-Centre, Pneumology and Immunology, Charité School of Medicine, Free University and Humboldt-University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Poutanen, Susan M" sort="Poutanen, Susan M" uniqKey="Poutanen S" first="Susan M" last="Poutanen">Susan M. Poutanen</name><affiliation wicri:level="1"><nlm:aff id="aff3">Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto</nlm:aff><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E" last="Low">Donald E. Low</name><affiliation wicri:level="1"><nlm:aff id="aff3">Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff4">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto</nlm:aff><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Department of Medicine, University of Toronto, Toronto</nlm:aff><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lode, Hartmut" sort="Lode, Hartmut" uniqKey="Lode H" first="Hartmut" last="Lode">Hartmut Lode</name><affiliation wicri:level="3"><nlm:aff id="aff6">Department of Chest and Infectious Diseases, Hospital Heckeshorn, Free University Berlin, Berlin</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Berlin</settlement><region type="land" nuts="2">Berlin</region></placeName><wicri:orgArea>Department of Chest and Infectious Diseases, Hospital Heckeshorn, Free University Berlin</wicri:orgArea></affiliation></author><author><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Pneumology, Hannover Medical School, Hannover, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pneumology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Zabel, Peter" sort="Zabel, Peter" uniqKey="Zabel P" first="Peter" last="Zabel">Peter Zabel</name><affiliation wicri:level="1"><nlm:aff id="aff7">Division of Clinical Infectiology and Immunology, Department of Medicine, Research Center Borstel, Borstel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Infectiology and Immunology, Department of Medicine, Research Center Borstel, Borstel</wicri:regionArea><wicri:noRegion>Borstel</wicri:noRegion><wicri:noRegion>Borstel</wicri:noRegion><wicri:noRegion>Borstel</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Lancet. Infectious Diseases</title><idno type="ISSN">1473-3099</idno><idno type="eISSN">1474-4457</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>The causative agent of severe acute respiratory syndrome (SARS), which affected over 8000 individuals worldwide and was responsible for over 700 deaths in the 2002–2003 outbreak, is a coronavirus that was unknown before the outbreak. Although many different treatments were used during the outbreak, none were implemented in a controlled fashion. Thus, the optimal treatment for SARS is unknown. Since the outbreak, much work has been done testing new agents against SARS using in-vitro methods and animal models. In addition, global research efforts have focused on the development of vaccines against SARS. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Lancet Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Lancet Infect Dis</journal-id><journal-title-group><journal-title>The Lancet. Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1473-3099</issn><issn pub-type="epub">1474-4457</issn><publisher><publisher-name>Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15766649</article-id><article-id pub-id-type="pmc">7106466</article-id><article-id pub-id-type="publisher-id">S1473-3099(05)01307-1</article-id><article-id pub-id-type="doi">10.1016/S1473-3099(05)01307-1</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Treatment and vaccines for severe acute respiratory syndrome</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Groneberg</surname><given-names>David A</given-names></name><degrees>Dr</degrees><email>david.groneberg@charite.de</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="aff2" ref-type="aff">b</xref><xref rid="cor1" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Poutanen</surname><given-names>Susan M</given-names></name><xref rid="aff3" ref-type="aff">c</xref><xref rid="aff4" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Low</surname><given-names>Donald E</given-names></name><xref rid="aff3" ref-type="aff">c</xref><xref rid="aff4" ref-type="aff">d</xref><xref rid="aff5" ref-type="aff">e</xref></contrib><contrib contrib-type="author"><name><surname>Lode</surname><given-names>Hartmut</given-names></name><xref rid="aff6" ref-type="aff">f</xref></contrib><contrib contrib-type="author"><name><surname>Welte</surname><given-names>Tobias</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Zabel</surname><given-names>Peter</given-names></name><xref rid="aff7" ref-type="aff">g</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Department of Pneumology, Hannover Medical School, Hannover, Germany</aff><aff id="aff2"><label>b</label>Otto-Heubner-Centre, Pneumology and Immunology, Charité School of Medicine, Free University and Humboldt-University, Berlin, Germany</aff><aff id="aff3"><label>c</label>Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Toronto, Ontario, Canada</aff><aff id="aff4"><label>d</label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto</aff><aff id="aff5"><label>e</label>Department of Medicine, University of Toronto, Toronto</aff><aff id="aff6"><label>f</label>Department of Chest and Infectious Diseases, Hospital Heckeshorn, Free University Berlin, Berlin</aff><aff id="aff7"><label>g</label>Division of Clinical Infectiology and Immunology, Department of Medicine, Research Center Borstel, Borstel, Germany</aff><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Dr D A Groneberg, Otto-Heubner-Centre, Pneumology and Immunology, Charité School of Medicine, Augustenburger Platz 1 OR-1, 13353 Berlin, Germany. Tel +49 304 5055 9055; fax: +49 304 5055 9951 <email>david.groneberg@charite.de</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>10</day><month>3</month><year>2005</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>3</month><year>2005</year></pub-date><pub-date pub-type="epub"><day>10</day><month>3</month><year>2005</year></pub-date><volume>5</volume><issue>3</issue><fpage>147</fpage><lpage>155</lpage><permissions><copyright-statement>Copyright © 2005 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2005</copyright-year><copyright-holder>Elsevier Ltd</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract><title>Summary</title><p>The causative agent of severe acute respiratory syndrome (SARS), which affected over 8000 individuals worldwide and was responsible for over 700 deaths in the 2002–2003 outbreak, is a coronavirus that was unknown before the outbreak. Although many different treatments were used during the outbreak, none were implemented in a controlled fashion. Thus, the optimal treatment for SARS is unknown. Since the outbreak, much work has been done testing new agents against SARS using in-vitro methods and animal models. In addition, global research efforts have focused on the development of vaccines against SARS. Efforts should be made to evaluate the most promising treatments and vaccines in controlled clinical trials, should another SARS outbreak occur.</p></abstract></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>Canada</li></country><region><li>Basse-Saxe</li><li>Berlin</li><li>Ontario</li></region><settlement><li>Berlin</li><li>Hanovre</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Groneberg, David A" sort="Groneberg, David A" uniqKey="Groneberg D" first="David A" last="Groneberg">David A. Groneberg</name></region><name sortKey="Groneberg, David A" sort="Groneberg, David A" uniqKey="Groneberg D" first="David A" last="Groneberg">David A. Groneberg</name><name sortKey="Lode, Hartmut" sort="Lode, Hartmut" uniqKey="Lode H" first="Hartmut" last="Lode">Hartmut Lode</name><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name><name sortKey="Zabel, Peter" sort="Zabel, Peter" uniqKey="Zabel P" first="Peter" last="Zabel">Peter Zabel</name></country><country name="Canada"><noRegion><name sortKey="Poutanen, Susan M" sort="Poutanen, Susan M" uniqKey="Poutanen S" first="Susan M" last="Poutanen">Susan M. Poutanen</name></noRegion><name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E" last="Low">Donald E. Low</name><name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E" last="Low">Donald E. Low</name><name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E" last="Low">Donald E. Low</name><name sortKey="Poutanen, Susan M" sort="Poutanen, Susan M" uniqKey="Poutanen S" first="Susan M" last="Poutanen">Susan M. Poutanen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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